Listeria monocytogenes genes supporting growth under standard laboratory cultivation conditions and during macrophage infection

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Figure 6.
Figure 6.

Novel genes contributing to L. monocytogenes growth inside macrophages. (A) Growth of L. monocytogenes strains EGD-e (wt), LMS250 (Δhly), LMJR87 (ΔcozEb), LMS283 (ΔwalJ), LMS284 (ΔftsK), LMS290 (ΔparA), and LMS305 (ΔgcvPAB) in BHI broth. (B) Intracellular growth of the same set of strains in J774 mouse macrophages. Average values and standard deviations were calculated from triplicates. (C) Plaque formation assay testing cell-to-cell spread of the ΔgcvPAB mutant (strain LMS305) in 3T3 mouse embryo fibroblasts. L. monocytogenes strains EGD-e (wt) and LMS250 (Δhly) were included for control.

This Article

  1. Published in Advance September 16, 2022, doi: 10.1101/gr.276747.122 Genome Res. 32: 1711-1726

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