dbEmbryo multi-omics database for analyses of synergistic regulation in early mammalian embryo development

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Figure 5.
Figure 5.

Multifaceted regulation of epigenetic marks at ICM stage. (A) Scatter plots show the correlations between gene expression (GSE66582) and epigenetic signals (ATAC-seq: GSE66581; H3K4me3: GSE71434; H3K9me3: GSE97778; H3K27me3: GSE76687; mCG/CG: GSE56697) in promoters (2 kb upstream of TSSs). Correlation coefficients were calculated by Pearson's linear correlation. (B) Heatmaps show the enrichment of epigenetic marks (ATAC-seq: GSE66581; H3K4me3: GSE71434; H3K9me3: GSE97778; H3K27me3: GSE76687; mCG/CG: GSE56697; normalized RPKM) in the ICM stage; a bar chart shows the expression level of corresponding genes. (C,D) UCSC plots show epigenetic signals (ATAC-seq: GSE66581; H3K4me3: GSE71434; H3K9me3: GSE97778; H3K27me3: GSE76687; mCG/CG: GSE56697) surrounding Zfp106, Snap23, Zfp639, Rhox13, Defb7, Usp29, Top3a, Gnas, and Vnn1. The bar plot shows gene expression level.

This Article

  1. Published in Advance August 17, 2022, doi: 10.1101/gr.276744.122 Genome Res. 32: 1612-1625

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