
A digital art illustration entitled “The hijack, identity and Darwin” representing epigenetic changes at oncogenes and the transformation of normal cells to malignant cells. Note how the change of location (from sky to sea) results in a change of color but maintenance of shape. In this issue, three related articles offer insights into how H3K4me3 broad domains are hijacked by oncogenes from cell identity genes. (Cover artwork by Dimple Devadas, https://www.volvehealth.co.uk/. [For details, see Belhocine et al., pp. 1328–1342; Mikulasova et al., pp. 1343–1354; and Rico et al., pp. 1355–1366.])