Genetic, epigenetic, and environmental mechanisms govern allele-specific gene expression

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Figure 1.
Figure 1.

Evaluating ASE across tissues and environmental contexts. We partitioned ASE into its parent-of-origin and sequence effects, then compared ASE patterns across metabolic tissues, in response to dietary fat and between sexes. An example of parent-of-origin-dependent ASE is when the maternal allele (red) is preferentially expressed over the paternal allele (blue), regardless of which haplotype contributed it. An example of sequence-dependent ASE is when the LG/J allele is preferentially expressed over the SM/J allele, regardless of which parent contributed it.

This Article

  1. Genome Res. 32: 1042-1057

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