Figure 7.
The H3K27, H3K36, and DNAme interaction network. (A) The principal interaction network in mESCs, with the central role of H3K36me2. The dashed line represents the weaker influence of the DNAme-H3K27me axis; however, the relative strengths of those interactions may differ across cell types. (B) Molecular cartoon illustrating the state of this three-component system across five distinct genomic compartments and showing how disturbing each of the components affects the system.
