X-linked genes can be compensated by their Y-linked paralogs. (A) Distribution of essentiality scores for four X-linked genes that are more essential in cell lines without a Y Chromosome. The gray line is the average across the cell lines. The black lines are the mean value for each group. (B) Significant correlation between the essentiality score of the four X-linked genes and the expression of their Y-linked paralogs. The lines are locally estimated scatterplot smoothing (LOESS) curves ±95% confidence intervals. (C) Paralog sequence identity as a function of essentiality scores. Eight genes are highlighted with relatively high essentiality scores and sequence identity with the Y-linked paralog.
