Systematic evaluation of the effect of polyadenylation signal variants on the expression of disease-associated genes

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Figure 3.
Figure 3.

Distinct features of PAS-located pathogenic variants and their associations with human diseases. (A) Classification of disease-associated variants located in the PASs. (B) The distribution difference between pathogenic and benign variants in the 13 shared PASs. (C) The position preferences between pathogenic and benign variants in the PAS. The x-axis denotes six positions (1–6) of the PAS. (*) P < 0.05, (**) P < 0.01, Fisher's exact test.

This Article

  1. Published in Advance April 19, 2021, doi: 10.1101/gr.270256.120 Genome Res. 31: 890-899

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