Functional categories of nonadditive genes in F1 hybrids of wild S. cerevisiae. (A) Heatmap shows the clustering of nonadditive genes based on their expression levels in each F1 hybrid relative to the average expression levels of the genes in the parents (MPV) of the hybrid according to the scale on the right, which depicts the values of log2 (F1/MPV). (B,D) Nonredundant Gene Ontology (GO) terms significantly enriched with the nonadditive genes in groups I and II, respectively. P-values represent statistical significance. (C,E) Enrichment networks show the intra- and inter-cluster functional similarities of the enriched GO terms shown in B and D, respectively. Enrichment networks are created by representing each enriched term as a node and connecting pairs of nodes with kappa similarities above 0.3. Up to 10 terms represented by colored nodes are included per cluster. The color code is respectively the same with that in B and D. The sizes of the nodes are proportional to the numbers of input genes falling into the terms.
