Figure 5.
Sir3-bound regions coincide with long-range contacts. (A) Intra-chromosomal ratio plots of Chromosome I, VI, and IV-L contact maps generated in sir3-A2Q OE and SIR3 OE conditions and processed by Serpentine binning. The ChIP deposition profile of Sir3 in OE conditions are plotted along the top and right axis. Intra-chromosomal loci enriched in Sir3 are indicated by the closest gene name. (B) Serpentine binning plots recapitulating the enrichment in contacts in SIR3 OE conditions with respect to sir3-A2Q OE conditions, showing Chromosomes I, IV, V, and VI interacting with the rest of the genome. (C) Schematic representation of the behavior of internal Sir3 binding sites in different conditions.
