Topologically associating domains and their role in the evolution of genome structure and function in Drosophila

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Figure 5.
Figure 5.

Evolutionary genome rearrangement breakpoints are enriched at Drosophila TAD boundaries. (A) Synteny map between D. melanogaster 2L and D. pseudoobscura Chr 4. Tracks are as follows: (a) HiCExperor TAD boundaries annotated at restriction fragment resolution, (b) 10-kbp resolution, and (c) synteny breakpoints. (B) Phylogeny of 17 Drosophila species. Estimated divergence times are obtained from Thomas and Hahn (2017) except for Drosophila triauraria. (C) Distribution of genome rearrangement breakpoints between D. melanogaster and four other Drosophila species along TAD regions. (D) Distribution of genome rearrangement breakpoints between D. pseudoobscura and four species along TAD regions. (E) Conservation of TADs in an inverted genomic segment (D. melanogaster 2L: 8.55–8.95 Mb) between D. melanogaster and D. pseudoobscura.

This Article

  1. Published in Advance February 9, 2021, doi: 10.1101/gr.266130.120 Genome Res. 31: 397-410

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