Blood-derived mitochondrial DNA copy number is associated with gene expression across multiple tissues and is predictive for incident neurodegenerative disease

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Figure 3.
Figure 3.

Observed genomic inflation factors are significantly different from permuted genomic inflation factors for certain tissues. A higher genomic inflation factor represents increased global associations between blood-derived mtDNA-CN and gene expression in a specific tissue. One thousand permuted genomic inflation factors were obtained using two-stage permutation testing. Red line represents permuted lambda cutoff of 1.20.

This Article

  1. Published in Advance January 13, 2021, doi: 10.1101/gr.269381.120 Genome Res. 31: 349-358

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