Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives

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Figure 5.
Figure 5.

CB2 outperforms MAGeCK and PinAPL-Py in the percentage of mapped reads over six benchmark data sets. (A) Read mappability of CB2, MAGeCK, and PinAPL-Py across six different data sets. (B) Representative examples of reads that were not mapped by MAGeCK or PinAPL-Py. Adapters are highlighted with green; sgRNAs, with red. Yellow boxes show the predicted locations of sgRNAs by each method. Several parameters were used to optimize performances of PinAPL-Py.

This Article

  1. Published in Advance April 23, 2019, doi: 10.1101/gr.245571.118 Genome Res. 29: 999-1008

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