Beta-binomial modeling of CRISPR pooled screen data identifies target genes with greater sensitivity and fewer false negatives

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Figure 4.
Figure 4.

Discrepancy of sgRNA-level statistics between CB2 and MAGeCK in two public CRISPR pooled screens. (A) Heatmaps of normalized read counts of the detected sgRNAs from the screen data of Parnas et al. (2015). (Left) A heatmap of sgRNAs detected by CB2 only. (Right) A heatmap of sgRNAs detected by MAGeCK only. (B) Venn diagrams of sgRNAs detected by CB2 and MAGeCK from the screen data of Parnas et al. (2015). (C,D) Same representations of A and B using data from Li et al. (2018).

This Article

  1. Published in Advance April 23, 2019, doi: 10.1101/gr.245571.118 Genome Res. 29: 999-1008

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