Schematic representation of the five main steps of the clustering of genomic regions analysis method (CREAM). For step 1, CREAM identifies all groups of two, three, four, and more neighboring CREs. The total number of CREs in a group defines its “Order.” Step 2 is identification of the maximum window size (MWS) between two neighboring CREs in group for each Order. The MWS corresponds to the greatest distance allowed between two neighboring CREs in a given cluster. Step 3 is identification of the maximum Order limit of COREs from a given data set. Step 4 is CORE reporting according to the criteria set in step 3 from the highest to the lowest Order. Step 5 is identification of the minimum Order limit of COREs based on the identified COREs in step 4.
