The extent and timing of GC-responsive changes in TF binding, histone modifications, and accessibility in enhancers. (A) Bar plot shows the proportion of enhancers with differential ChIP-seq or DNase-seq signal at some dex exposure time point compared with pre-dex levels. To be called differential, an enhancer also had to have enriched signal above background, i.e., a peak, at some point in the time course. (B) Line plot represents cumulative proportion of enhancers with increasing signal at or prior to each time point, scaled to unity, and smoothed by piecewise cubic Hermite interpolating polynomial splines. (C) Same as B, except for enhancers with decreasing signal.
