Figure 1.
Noncanonical secondary structures arising from non-B DNA motifs in the human genome. (A) Normal configuration of human DNA. (B) Left-handed helical structure caused by Z-DNA. (C–F) Schematic representations of the primary sequence of various non-B motifs and their corresponding predicted secondary structures. (G) Length distribution of non-B DNA motifs. (H) Fraction of the human reference genome (hg19) covered by different non-B DNA motifs. (I) Enrichment of occurrences of non-B DNA motifs associated with various chromatin states (see Methods for calculation).
