Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

Figure 2.
Figure 2.

SDEGs located in the autophagy-lysosomal pathway. (A) Circos representation of the SDEGs (Krzywinski et al. 2009). (B) Heat map plot for the up-regulated SDEGs in CENs compared to F1SPs. (C) qRT-PCR validation for expression of four SDEGs in 20 CENs and four F1SPs. (D) Frequencies of CENs harboring up-regulated autophagy-lysosomal SDEGs. (E) Serum beclin 1 levels in longevity families. (*) P < 5.0 × 10−2.

This Article

  1. Published in Advance October 23, 2018, doi: 10.1101/gr.220780.117 Genome Res. 28: 1601-1610

Preprint Server



Current Issue

  1. March 2026, 36 (3)
  1. Current Issue
  1. Alert me to new issues of Genome Research