TBR1 binds near high-confidence ASD genes. (A) Regulatory domains of Grin2b with eight adjacent TBR1 ChIP-seq peaks and Auts2 with 22 adjacent TBR1 ChIP-seq peaks. (B) Significance of the number of TBR1 ChIP-seq peaks adjacent to each high-confidence ASD gene set given the total number of peaks and size of the genomic regions used to associate peaks with their adjacent genes (the negative logarithm of the GREAT binomial P-value; x-axis) compared to the significance of the number of high-confidence ASD genes with an adjacent TBR1 peak given the total number of genes with an adjacent TBR1 peak (negative logarithm of the GREAT hypergeometric P-value; y-axis). Enrichment compared to E14.5 neocortex EP300 ChIP-seq, E15.5 neocortex SATB2 ChIP-seq, and 28 ENCODE ChIP-seq sets including tissues at different developmental time-points and primary cell lines. Dashed gray lines represent P = 0.05 significance level.
