Cancer-specific antisense loci. (A) Presence/absence heatmap of significantly expressed antisense loci found in lung cancer tissues (LUAD, LUSC) but not in benign samples. Presence in other cancer tissues, breast cancer (BRCA), pancreatic cancer (PANC), prostate cancer (PRCA), meningioma (MENG), and the lung cancer cell lines (LUCL) is also shown. All loci depicted in the heatmap involve protein-coding genes, and the gene names displayed are therefore for the cognate genes. Loci present in a particular cancer subtype are indicated by red, whereas absent loci are indicated by beige. (B) Lung cancer-specific antisense loci. Presence/absence heatmap of antisense loci significantly expressed in LUAD and LUSC but not in lung normal samples (n = 1772). Of these, 1212 were also present in in the LUCL cohort. Color scale as in A. (C) Cancer-specific antisense loci involving tumor suppressors or oncogenes (n = 44). Color scale as in A.
