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In-depth analysis of intra-tumoral genetic heterogeneity with high-throughput single-cell copy number profiling. Cartoon depiction of single-cell genomes from a breast cancer biopsy illustrating the genetic heterogeneity inherent in cancer genomes. Arrows point to mosaic amplicons containing genes with suspected involvement in cancer. (Cover illustration by Bartek Jacewicz, b.jacewicz@gmail.com. [For details, see Baslan et al., pp. 714–724.])

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