Single-cell-level spatial gene expression in the embryonic neural differentiation niche

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Figure 4.
Figure 4.

NP network module interfaces are enriched for “differentiation” functions. (A) The NP network between the six Clusters (423 nodes/genes in the network). Red edges represent PPIs between two transcriptionally correlated (PCC > 0.2) genes across the space from VZ to CP on the ISH images, while blue edges are those with PCC < −0.2. (B) Distribution of CIs with the keyword “differentiation” for the indicated gene sets. (C) Relationship between AvgPCC of genes/nodes (binned at linear intervals, at least five nodes in each bin) and the fraction of genes of at least three PubMed co-citations (CI ≥ 2) with the word “differentiation” within each bin. Gray lines indicate the average background levels.

This Article

  1. Genome Res. 25: 570-581

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