Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins

Putative loss-of-function alterations in RLF genes across tumor types. The proportion of tumors that carry heterozygous loss or mutation of MCM2-7 individually or as a group and all RLFs (MCM2-7, CDC6, CDT1, and ORC1-6) as indicated in the key across different cancer types: AML, Acute Myeloid Leukemia; BUC, Bladder Urothelial Carcinoma; BIC, Breast Invasive Carcinoma; CSCC, Cervical Squamous Cell Carcinoma and Endocervical Carcinoma; CRA, Colon and Rectum Adenocarcinoma; GBM, Glioblastoma Multiforme; HNSC, Head and Neck Squamous Cell Carcinoma; KRCC, Kidney Renal Clear Cell Carcinoma; LAC^T, Lung Adenocarcinoma (TCGA Provisional); LAC^B (Broad); LSCC, Lung Squamous Cell Carcinoma; OSC, Ovarian Serous Cystadenocarcinoma; PAC, Prostate Adenocarcinoma; SCM, Skin Cutaneous Melanoma; SAC, Stomach Adenocarcinoma; TC, Thyroid Carcinoma; UCEC, Uterine Corpus Endometrioid Carcinoma.