Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity

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Figure 5.
Figure 5.

rs181194611 (p.P1244L) associated with nondiabetic ESKD impairs SHROOM3 function in vivo. (A) Proline at the amino acid position 1244 in SHROOM3 is evolutionarily conserved. (B) Representative images of dorsal aorta at 1, 24, and 48 h following 70-kDa dextran injection are shown. (C) Co-injection of nonmutated human SHROOM3 mRNA restored normal glomerular permeability, while ∆P1244L failed to show functional rescue. (*) P < 0.05 vs. uninjected.

This Article

  1. Published in Advance October 1, 2014, doi: 10.1101/gr.182881.114 Genome Res. 25: 57-65

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