Figure 1.
Karyotype-wide mapping of the regions with human-specific enrichment (n = 410, blue) and depletion (n = 61, green) of H3K4me3 modifications in prefrontal neurons. The localizations of the 33 human-specific loci selectively methylated in neuronal versus nonneuronal cells are similarly pinpointed in red (n = 33 regions). The human-specific pericentric inversion breakpoints (BP1 and BP2) of HSA1 and HSA18, the fusion point (FP) and ancestral centromere (AC) of HSA2, and the 16p11.2–12.2 and 3p26.3 regions mentioned in the text are indicated.
