Figure 8.
Validation of novel sites and the strain variability of C-to-T editing. Representative examples of Sanger sequencing chromatograms for editing of Itgb2, at chr10:77028356 (A); Msn, at chrX:93363499 (B); and Ctnnb1, at chr9:120869190 (C) in AJ and B6 macrophages. (D) Also shown is a previously confirmed edited site in Tmbim6 at chr15:99239051, which we used, together with the novel sites, to show the variability (chromatogram height for the nonreference base) of APOBEC1 editing activity in AJ and B6 macrophages.
