Figure 7.
APOBEC1-mediated mRNA editing is genetic. Using linkage analysis and the rate of editing at previously confirmed sites on the 3′ UTR of B2m (A), App (B), and Tmbim6 (C) in murine macrophages, we show that APOBEC1-mediated editing is genetic and linked to the same genetic marker as the Apobec1 sQTL on chromosome 6. The Apobec1 sQTL is shown in black, and the edQTL for each gene is indicated in gray. While significant sQTL were identified at adjusted P < 0.05 after 1000 permutations in R/qtl, we show on the plots the actual adjusted P-values for each edQTL and the Apobec1 sQTL.
