Apobec1 isoform usage and editing activity is variable between mouse strains. (A) Isoform usage for Apobec1 varies between the mouse strains, independent of the stimulus, which is confirmed by averaging the PSI values in the RI mice based on the genotype at the Apobec1 sQTL (B). (C) Like the isoform usage, the Apobec1 mRNA level is variable between the mouse strains, independent of the stimulus. (D) The rate of editing does not significantly vary between macrophage conditions, except for CpG-stimulated macrophages, which generally have lower rates of editing. The average PSI or FPKM values for RI lines having the AJ Apobec1 sQTL allele is represented by the gray bars and B6 allele by the black bars (mean ± SD, [ns] not significant, [***] P < 0.05, Student's t-test).
