The rate of APOBEC1-mediated editing is dependent on the mouse genetic background. We observed strain-specific variable rates of editing at previously confirmed APOBEC1-edited sites in a set of genes expressed in macrophages. Using the genotype at the Apobec1 sQTL to distinguish the RI mice followed by averaging the rate of editing in mice with the same genotype (∼13 for each genotype), we show that the rate of editing at these previously identified sites varies between macrophages with the AJ (gray) and B6 (black) genotypes. All the genes, except App, were reported to have a single APOBEC1 edited site. For App, only one site supported by the most number of reads was considered (mean ± SD, [***] P < 0.001, [*] P < 0.05, Student's t-test).
