The genetic basis for individual differences in mRNA splicing and APOBEC1 editing activity in murine macrophages

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Figure 4.
Figure 4.

Linkage analysis of splicing events in RI mice reveals distinct trans splicing QTL (trans-sQTL). Shown is a representative of a trans-sQTL enrichment (trans-sQTL hotspot) on chromosome 5 in IFNG/TNF-stimulated macrophages. The linkage analysis was based on PSI values across 26 recombinant inbred AXB/BXA mice. QTL significance was estimated at adjusted P < 0.05 after 1000 permutation tests in R/qtl and FDR ≤ 10%. Each dot represents an individual event, and the circles indicate events within a 10-Mb window.

This Article

  1. Published in Advance November 18, 2013, doi: 10.1101/gr.166033.113 Genome Res. 24: 377-389

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