Figure 2.
Stimulus-specific differential splicing. Even though isoform usage for Samhd1 was the same between the strains, we observed stimulus-specific differential isoform usage for Samhd1 between IFNG/TNF-stimulated and infected BMDM. The Samhd1 event is due to the skipping of the 14th exon, and the alternative isoform is known to be metabolically unstable and catalytically (dNTPase activity) inactive. Shown are the PSI (ψ) for the longest isoform for each strain, and the lower and upper 95% CIs (in parentheses).
