Cover image

Cover A portrait representative of a Paleo-Eskimo individual of the Saqqaq culture from Greenland. Recent advances in ancient DNA research have allowed the sequencing of complete ancient genomes from short DNA molecules preserved in the fossil record for thousands, and sometimes even hundreds of thousands, of years. It was unknown, however, whether ancient epigenomes could be reconstructed. In this issue, the first ancient epigenome is reconstructed using DNA sequence information retrieved from the hairs of a 4000-yr-old Paleo-Eskimo individual. (Cover illustration by Nuka Konrad Gotfredsen, www.andala.dk. [For details, see Pedersen et al., pp. 454–466.])