Figure 5.
Gcr1 binding sites have complex effects on expression. (A) When Gcr11 sites are added to promoters containing only Reb11 or Rap11 TFBSs, their effect is to increase the activation of gene expression. However, when Gcr11 sites are added to promoters containing only Mig11 sites, their effect on gene expression is repressive. (B) Gcr11 TFBS has a weaker repressive effect when added to low-affinity Mig1 sites (Mig12 and Mig13). (C) Gcr1 TFBS with low affinity (Gcr13 and Gcr12) have weak repressive interactions when combined with high-affinity Mig1 sites (Mig11).
