Cover image

Cover Drawing illustrates the concept of crowdsourcing to solve the code that relates DNA sequences to promoter activities. Trucks represent the participants of the DREAM6 Gene Promoter Expression Prediction challenge, each contributing different sequence features that predict RNA expression. RNA expression levels are denoted by the different number of RNA molecules carried by the trucks. These contributions are integrated via the crane on top of a chromosome. The crane represents the “machine-learning” approach that transforms the DNA sequences brought by the participants (and present in the chromosome) into promoter activities (i.e., the crane transporting RNA into the trucks), hence closing the loop of knowledge. (Cover illustration by Ricardo Cid, http://blacklabelrobot.com. [For details, see Meyer et al., pp. 1928–1937.])