Cover image
Cover Hepatitis B virus infects human hepatocytes and randomly integrates its genome (depicted in green-yellow) into the human DNA. Such viral integration causes various genomic perturbations, occasionally affecting cancer-related genes. Clonal expansion of hepatocytes with specific integrations can be seen in tumor samples but not in the noncancerous tissues. (Cover illustration by Allison Bruce, Genentech, Inc. [For details, see Jiang et al., pp. 593–601.])
