Figure 1.
Genomic locations of H3K27ac, H3K4me1, and H3K4me3. (A) A schematic representation of zebrafish early development. H3K4me1/me3 and H3K27ac were immunoprecipitated at the described stages. (B) UCSC Genome Browser view of H3K27ac, H3K4me1, and H3K4me3 tracks obtained for four zebrafish developmental stages: dome, 80% epiboly, 24 hpf, 48 hpf. (Red asterisks) Previously described neurog1 enhancers. (C) Endogenous expression pattern of neurog1 at 80% epiboly, 24-hpf, and 48-hpf zebrafish embryos driven by H3K4me1/H3K27ac-marked transcriptional enhancers. The transcript is localized along the central nervous system (forebrain, midbrain, hindbrain, and spinal cord).
