Figure 4.
PcG proteins bind nonannotated TSSs. (A) 5′-MACE detects annotated transcription starts shown by metagene analysis of the read distribution. (B) 5′-MACE detects a TSS cluster far from known promoter regions. The red line marks a distance of ±500 bp. (C) PcG binding sites in S2 cells scattered according to their distance to the RefSeq TSS and TSS cluster found by 5′-MACE. The crosshair marks a distance of ±500 bp, and the newly identified PcG-bound promoter can be found in the lower right quarter.
