Cover image

Cover A repeating pattern of Drosophila melanogaster (common fruit flies) and Caenorhabditis elegans (roundworms) is shown. Both organisms are targets of the National Human Genome Research Institute model organism ENCyclopedia Of DNA Elements (modENCODE) project, which seeks to identify the functional elements across the genomes of these two widely used experimental organisms. The patterns coloring the worms and flies represent the multiple data types and analyses reported in this special issue of Genome Research. (Cover illustration by Adrienne Waterston [http://aquadesign.us], adapted from an illustration by Michael Leykin [http://www.leykin.com], with original concept contributions from Peter Kharchenko and Gary H. Karpen.)