A novel mode of enhancer evolution: The Tal1 stem cell enhancer recruited a MIR element to specifically boost its activity

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Figure 5.
Figure 5.

Evolution of the Tal1 stem cell enhancer region. (A) Multiple species sequence alignment of the +18 region detected in eight of the mammals analyzed. Mm, Mus musculus; Rn, Rattus norvegicus; Hs, Homo sapiens; Bt, Bos taurus; Fc, Felis catus; Cf, Canis familiaris; La, Loxodonta africana; Ee, Erinaceus europaeus. (B) Phylogentic tree depicting the divergence of the species listed on the right (adapted from Murphy et al. 2007). Time window for the insertion of the Tal1 +18 region is indicated. Md, Monodelphis domestica; Oa, Ornitorhynchus anatinus.

This Article

  1. Published in Advance August 7, 2008, doi: 10.1101/gr.077008.108 Genome Res. 18: 1422-1432

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