Origin of INSL3-mediated testicular descent in therian mammals

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Figure 5.
Figure 5.

Ablation of LGR7-activation activity of AncRFLC and restoration of lost LGR7-activation activity in human INSL3 by point mutation. (A–C) LGR7 (RXFP1)- and LGR8 (RXFP2)-activation activity of AncRFLC RB12H, zRFLC1 RB12H, and zRFLC2 RB12H peptides (A), opossum INSL3 peptide (oINSL3) (B), and INSL3 HB12R and INSL3 HB12A peptides (C). Mean ± SEM, N = 4.

This Article

  1. Published in Advance May 7, 2008, doi: 10.1101/gr.7119108 Genome Res. 18: 974-985

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