Defensins and the dynamic genome: What we can learn from structural variation at human chromosome band 8p23.1

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Figure 2.
Figure 2.

Evolution of the DEFA1A3 CNV region. Following an initial de novo duplication at least 25 Mya, recurrent ectopic recombination generates long arrays of DEFA1 repeats. A point mutation in humans generates the DEFA3 gene, which is shuffled through the array by continuing ectopic recombination.

This Article

  1. Genome Res. 18: 1686-1697

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