Figure 1.
(A) Schematic view of the chromatin measurements. Nucleosome positions were predicted based on the hybridization of MNase-digested pre-extracted chromatin against differentially labeled MNase-digested bare genomic DNA. (B) Agarose gel separation showing nucleosome-sized DNA fragments (arrow) in K562 and HeLa after MNase digestion. (C) Tiling of the DNA microarray used for chromatin measurements: 50-bp probes were tiled with 5-bp steps on both strands.
