Callipyge mutation affects gene expression in cis: A potential role for chromatin structure

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Figure 1.
Figure 1.

Structure of the genomic region spanning the callipyge locus. Schematic representation of the telomeric end of ovine chromosome 18, and the genes present within the proximity of the callipyge mutation (A→G) on both the maternal (MAT) and paternal (PAT) chromosomes. Gene designations in mice are given in parentheses. The callipyge mutation (position 103,894 of AF354168) is contained within the transcribed CLPG1 locus. The direction of transcription is designated by the arrowheads representing each gene, with dark arrowheads representing actively transcribed alleles and translucent arrowheads representing silenced alleles for imprinted genes.

This Article

  1. Genome Res. 16: 340-346

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