Physicochemical constraint violation by missense substitutions mediates impairment of protein function and disease severity

Supplemental Research Data

Files in this Data Supplement:

• Hemoglobin_Alignment_fasta.txt
• Hemoglobin_Data.txt
• Hemoglobin_Info.txt
• Hemoglobin_Predictions.txt
• Hemoglobin_Scores.txt
• Hemoglobin_Weights.txt
• G6PD_Alignment_fa.txt
• G6PD_Data.txt
• G6PD_Info.txt
• G6PD_Predictions.txt
• G6PD_Scores.txt
• G6PD_Weights.txt
• Protease_Alignment_fa.txt
• Protease_CompSIFT.txt
• Protease_Data.txt
• Protease_Info.txt
• Protease_Performance.txt
• Protease_Polymorphism_Data.txt
• Protease_Predictions.txt
• Protease_Scores.txt
• Protease_Weights.txt
• RT_Alignment_fa.txt
• RT_CompSIFT.txt
• RT_Data.txt
• RT_Info.txt
• RT_Performance.txt
• RT_Predictions.txt
• RT_Scores.txt
• RT_Weights.txt
• LacI_Alignment_fa.txt
• LacI_CompSIFT.txt
• LacI_Data.txt
• LacI_Info.txt
• LacI_Orth_Alignment_fa.txt
• LacI_Orth_Data.txt
• LacI_Orth_Info.txt
• LacI_Orth_Performance.txt
• LacI_Orth_Predictions.txt
• LacI_Orth_Scores.txt
• LacI_Orth_Weights.txt
• LacI_Performance.txt
• LacI_Predictions.txt
• LacI_Scores.txt
• LacI_Tripartite_Alignmnt_fa.txt
• LacI_Tripartite_Data.txt
• LacI_Tripartite_Info.txt
• LacI_Tripartite_Performance.txt
• LacI_Tripartite_Predictions.txt
• LacI_Tripartite_Scores.txt
• LacI_Tripartite_Weights.txt
• LacI_Weights.txt
• P53_Alignment_fa.txt
• P53_Data.txt
• P53_Germline_Alignment_fa.txt
• P53_Germline_Data.txt
• P53_Germline_Predictions.txt
• P53_Germline_Scores.txt
• P53_Germline_Weights.txt
• P53_Predictions.txt
• P53_Scores.txt
• P53_Weights.txt
• PYK_Alignment_fa.txt
• PYK_Data.txt
• PYK_Info.txt
• PYK_Predictions.txt
• PYK_Scores.txt
• PYK_Weights.txt
• Lysozyme_Alignment_fa.txt
• Lysozyme_CompSIFT.txt
• Lysozyme_Data.txt
• Lysozyme_Info.txt
• Lysozyme_Performance.txt
• Lysozyme_Predictions.txt
• Lysozyme_Scores.txt
• Lysozyme_Weights.txt