Figure 2.
Generation of congenic rats from consomic strains. The parental strain is crossed with the consomic strain, to generate an F1 population with identical genetic background and a heterozygous target chromosome. These F1 rats are intercrossed to generate an F2 population of rats whose target chromosome will be congenic, because of recombination events. Two similar F2 rats are selected (by genotype) and mated to fix the region of interest. Reprinted with permission from Blackwell Publishing © 2004, from Cowley Jr. et al. (2004).
