Correction for Volume 13, p. 2485

Genome Research 13: 2485-2497 (2003)

Toward Rigorous Comprehension of Biological Complexity: Modeling, Execution, and Visualization of Thymic T-Cell Maturation

Sol Efroni, David Harel, and Irun R. Cohen

The authors inadvertently provided the wrong information for one of the references cited in the paper. The correct reference is as follows:

Meier-Schellersheim, M. 2001. “The immune system as a complex system: Description and simulation of the interactions of its constituents.” Ph.D. thesis, University of Hamburg, Germany.

Also, on page 2485, second column, the third paragraph should read:

“The task of specifying such a large data set needs its own special tools. As far as we know, Simmune (Meier-Schellersheim 2001) was the first software tool to provide an environment for the definition and interactive simulation of cellular behavior based on molecular interactions and cellular stimulus-response rules while taking into account the movement of the cells in spatial compartments. Without such tools, it is difficult to control the immense set of data. The tool we use for specification (and, as we will show later, also for integration) is the language of Statecharts (Harel 1987), a visual formalism invented to aid in the design of complex man-made reactive systems, and later proposed as a viable tool for specifying biological systems (N. Kam, I.R. Cohen, and D. Harel, in prep.). Below, we shall discuss the reasons for using this particular language. We begin here by detailing the problems mentioned above, as they arise in our model biological system—the thymus.”

The authors apologize for any confusion this may have caused.