Table 1.
IR-Responsive Genes in Common for Both 3 Gy and 10 Gy of IR Exposure
|
Accession no. |
Gene name |
Gene symbol |
3Gy cluster |
10 Gy cluster |
|---|---|---|---|---|
| Cell cycle | ||||
| X61123 | B-cell translocation gene 1, anti-proliferative | BTG1 | 7 | 2 |
| X51688 | cyclin A2 (probe 1943_at) | CCNA2 | 12 | 13 |
| X51688 | cyclin A2 (probe 40697_at) | CCNA2 | 12 | 13 |
| X77794 | cyclin G1 | CCNG1 | 7 | 3 |
| U05340 | CDC20 cell division cycle 20 homolog | CDC20 | 8 | 13 |
| U03106 | cyclin-dependent kinase inhibitor 1A (p21, Clp1) | CDKN1A | 11 | 0 |
| X54942 | CDC28 protein kinase 2 | CKS2 | 8 | 9 |
| M59287 | CDC-like kinase 1 (probe 32833_at) | CLK1 | 14 | 6 |
| HG3484-HT3678 | CDC-like kinase 1 (probe 292_s_at) | CLK1 | 10 | 1 |
| AB013924 | lysosomal-associated membrane protein 3 | LAMP3 | 3 | 3 |
| V00568 | v-myc myelocytomatosis viral oncogene homolog | MYC | 8 | 9 |
| U77735 | pim-2 oncogene | PIM2 | 6 | 6 |
| D38583 | S100 calcium binding protein A11 | S100A11 | 2 | 7 |
| X02530 | small inducible cytokine subfamily B, member 10 | SCYB10 | 12 | 4 |
| L08096 | tumor necrosis factor (ligand) superfamily, member 7 | TNFSF7 | 3 | 11 |
| U03398 | tumor necrosis factor (ligand) superfamily, member 9 | TNFSF9 | 11 | 4 |
| U58334 | tumor protein p53 binding protein, 2 | TP53BP2 | 14 | 4 |
| Cell death | ||||
| L22473 | BCL2-associated X protein | BAX | 3 | 11 |
| U45878 | baculoviral IAP repeat-containing 3 | BIRC3 | 6 | 6 |
| AF079221 | BCL2/adenovirus E1B 19 kD interacting protein 3-like | BNIP3L | 10 | 7 |
| L06797 | chemokine (C-X-C motif), receptor 4 | CXCR4 | 13 | 4 |
| U33838 | v-rel reticuloendotheliosis viral oncogene homolog A (probe 1045_s_at) | RELA | 0 | 11 |
| L19067 | v-rel reticuloendotheliosis viral oncogene homolog A (probe 1295_at) | RELA | 14 | 5 |
| AF016266 | tumor necrosis factor receptor superfamily, member 10b | TNFRSF10B | 15 | 1 |
| X83490 | tumor necrosis factor receptor superfamily, member 6 (probe 1440_s_at) | TNFRSF6 | 15 | 1 |
| X83492 | tumor necrosis factor receptor superfamily, member 6 (probe 1441_s_at) | TNFRSF6 | 15 | 1 |
| X63717 | tumor necrosis factor receptor superfamily, member 6 (probe 37643_at) | TNFRSF6 | 7 | 1 |
| Development | ||||
| X98296 | ubiquitin specific protease 9, X chromosome | USP9X | 10 | 6 |
| DNA metabolism | ||||
| D00591 | chromosome condensation 1 | CHC1 | 12 | 14 |
| M87339 | replication factor C (activator 1) 4 | RFC4 | 13 | 8 |
| D87012 | topoisomerase (DNA) III β | TOP3B | 0 | 15 |
| DNA repair | ||||
| U72649 | BTG family, member 2 | BTG2 | 6 | 3 |
| U18300 | damage-specific DNA-binding protein 2 | DDB2 | 3 | 3 |
| HG4074-HT4344 | flap structure-specific endonuclease 1 | FEN1 | 12 | 8 |
| M60974 | growth arrest and DNA-damage-inducible, α | GADD45A | 11 | 0 |
| U28946 | mutS homolog 6 | MSH6 | 13 | 8 |
| U78305 | protein phosphatase 1D magnesium-dependent, δ isoform | PPM1D | 15 | 0 |
| Metabolism | ||||
| U29344 | fatty acid synthase | FASN | 4 | 13 |
| J03826 | ferredoxin reductase | FDXR | 3 | 2 |
| J03459 | leukotriene A4 hydrolase | LTA4H | 10 | 2 |
| X04371 | 2′,5′-oligoadenylate synthetase 1 | OAS1 | 5 | 10 |
| X53793 | phosphoribosylaminoimidazole carboxylase | PAICS | 12 | 13 |
| D50840 | UDP-glucose ceramide glucosyltransferase | UGCG | 13 | 5 |
| Protein modification | ||||
| M91670 | ubiquitin carrier protein (probe 40619_at) | E2-EPF | 4 | 13 |
| M91670 | ubiquitin carrier protein (probe 893_at) | E2-EPF | 8 | 13 |
| A1912041 | heat shock 10 kD protein 1 (chaperonin 10) | HSPE1 | 8 | 13 |
| U60899 | mannosidase, α, class 2B, member 1 | MAN2B1 | 3 | 3 |
| RNA processing | ||||
| X79536 | heterogeneous nuclear ribonucleoprotein A1 | HNRPA1 | 14 | 0 |
| M65028 | heterogeneous nuclear ribonucleoprotein A/B | HNRPAB | 12 | 12 |
| Y12065 | nucleolar protein 5A | NOL5A | 8 | 12 |
| X75755 | splicing factor, arginine/serine-rich 2 | SFRS2 | 8 | 12 |
| U75679 | stem-loop (histone) binding protein | SLBP | 8 | 12 |
| Signaling | ||||
| U50939 | amyloid β precursor protein-binding protein 1 | APPBP1 | 13 | 4 |
| Z11697 | CD83 antigen | CD83 | 6 | 6 |
| M86868 | γ-aminobutyric acid (GABA) receptor, rho 2 | GABRR2 | 0 | 15 |
| AB001106 | glia maturation factor, β | GMFB | 14 | 4 |
| AF034633 | G protein-coupled receptor 39 | GPR39 | 0 | 14 |
| Z49835 | glucose regulated protein, 58 kD | GRP58 | 12 | 15 |
| Y10805 | HMT1 hnRNP methyltransferase-like 2 | HRMT-1L2 | 12 | 12 |
| M16038 | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | LYN | 1 | 5 |
| AC005775 | mucosal vascular addressin cell adhesion molecule 1 | MADCAM1 | 0 | 15 |
| X70070 | neurotensin receptor 1 | NTSR1 | 0 | 15 |
| U81802 | phosphatidylinositol 4-kinase, catalytic, β polypeptide | PIK4CB | 14 | 1 |
| J04130 | small inducible cytokine A4 | SCYA4 | 5 | 10 |
| Stress | ||||
| M86752 | stress-induced-phosphoprotein 1 | STIP1 | 13 | 13 |
| Structure | ||||
| U03851 | capping protein (actin filament) muscle Z-line α 2 | CAPZA2 | 14 | 4 |
| D14705 | catenin (cadherin-associated protein), α 1 | CTNNA1 | 10 | 3 |
| U60060 | fasciculation and elongation protein ζ 1 | FEZ1 | 2 | 3 |
| Transcription | ||||
| X74142 | forkhead box G1B | FOXG1B | 14 | 7 |
| Y09615 | transcription termination factor, mitochondrial | MTERF | 14 | 0 |
| AF012108 | nuclear receptor coactivator 3 | NCOA3 | 10 | 7 |
| U21858 | TAF9 RNA polymerase II | TAF9 | 14 | 4 |
| AB011076 | undifferentiated embryonic cell transcription factor 1 | UTF1 | 0 | 15 |
| L04282 | zinc finger protein 148 | ZNF148 | 15 | 1 |
| Transport | ||||
| U70322 | karyopherin (importin) β 2 | KPNB2 | 13 | 14 |
| X97544 | translocase of inner mitochondrial membrane 17 homolog A | TIMM17A | 13 | 4 |
| U94592 | uncoupling protein 2 | UCP2 | 2 | 7 |
| Other | ||||
| M13792 | adenosine deaminase | ADA | 2 | 7 |
| AF022991 | period homolog 1 | PER1 | 0 | 15 |
| No biological process GO listing | ||||
| X13839 | actin, α 2, smooth muscle, aorta | ACTA2 | 3 | 2 |
| AI800578 | S-adenosylhomocysteine hydrolase-like 1 | AHCYL1 | 10 | 2 |
| AB018328 | Ac-like transposable element | ALTE | 15 | 1 |
| L19871 | activating transcription factor 3 | ATF3 | 14 | 4 |
| W68046 | BTB (POZ) domain containing 2 | BTBD2 | 0 | 15 |
| D78586 | carbamoyl-phosphate synthetase 2 | CAD | 12 | 12 |
| M25753 | cyclin B1 (probe 1945_at) | CCNB1 | 9 | 9 |
| M25753 | cyclin B1 (probe 34736_at) | CCNB1 | 8 | 9 |
| L05424 | CD44 antigen (probe 1126_s_at) | CD44 | 2 | 6 |
| M59040 | CD44 antigen (probe 2036_s_at) | CD44 | 1 | 7 |
| L14813 | carboxyl ester lipase-like | CELL | 0 | 14 |
| M33653 | collagen, type XIII, α 1 | COL13A1 | 0 | 14 |
| U41387 | DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21 | DDX21 | 14 | 12 |
| AL050141 | hypothetical protein FLJ20719 | FLJ20719 | 6 | 10 |
| M29877 | fucosidase, α-L-1, tissue | FUCA1 | 3 | 3 |
| AI275093 | hairy and enhancer of split homolog 2 | HES2 | 0 | 11 |
| AL021546 | hypothetical protein HSPC132 | HSPC132 | 11 | 0 |
| W28616 | heat shock 90 kD protein 1, β | HSPCB | 13 | 0 |
| AI254524 | translation initiation factor IF2 | IF2 | 14 | 4 |
| AF026939 | interferon-induced protein with tetratricopeptide repeats 4 | IFIT4 | 10 | 6 |
| AI307607 | KIAA1096 protein | KIAA1096 | 13 | 0 |
| M25629 | kallikrein 1, renal/pancreas/salivary | KLK1 | 1 | 7 |
| Z49107 | lectin, galactoside-binding, soluble, 9 | LGALS9 | 2 | 7 |
| L37747 | lamin B1 | LMNB1 | 13 | 13 |
| D84557 | MCM6 minichromosome maintenance deficient 6 | MCM6 | 12 | 12 |
| AJ003147 | matrix metalloproteinase-like 1 | MMPL1 | 0 | 15 |
| W27995 | myosin, heavy polypeptide 10, non-muscle | MYH10 | 0 | 9 |
| AF052142 | neurocalcin δ | NCALD | 10 | 2 |
| X16277 | ornithine decarboxylase 1 | ODC1 | 12 | 13 |
| U30521 | P311 protein | P311 | 10 | 6 |
| AL080119 | PAI-1 mRNA-binding protein | PAI-RBP1 | 8 | 13 |
| Z29505 | poly(rC) bonding protein 1 | PCBP1 | 4 | 14 |
| AB028974 | paternally expressed 10 | PEG10 | 13 | 12 |
| AF010309 | quinone oxidoreductase homolog | PIG3 | 2 | 3 |
| M61906 | phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 | PIK3R1 | 14 | 1 |
| AB002313 | plexin B2 | PLXNB2 | 3 | 3 |
| L13977 | prolylcarboxypeptidase (angiotensinase C) | PRCP | 7 | 3 |
| W29065 | protein tyrosine phosphatase type IVA, member 3 | PTP4A3 | 0 | 14 |
| AA522530 | HIF-1 responsive RTP801 | RTP801 | 4 | 3 |
| AL050290 | spermidine/spermine N1-acetyltransferase | SAT | 2 | 7 |
| HG172-HT3924 | spermidine/spermine N1-acetyltransferase | SAT | 6 | 7 |
| M64231 | spermidine synthase | SRM | 12 | 12 |
| X92396 | synaptobrevin-like 1 | SYBL1 | 15 | 2 |
| X56841 | transketolase (Wernicke-Korsakoff syndrome) | TKT | 5 | 10 |
| X02883 | T cell receptor α locus | TRA | 10 | 2 |
| AL021306 | Human DNA sequence from clone CTB-1109B5 on chromosome 22 | N/A | 0 | 15 |
| AA806239
|
SNC73 protein
|
N/A
|
9
|
0
|
-
The numbers designated in the cluster columns refer to cluster number in Fig. 4.
