Identification of Potential Peroxisomal Proteins in Mouse
- Igor V. Kurochkin1,6,
- RIKEN GER Group2,
- GSL Members3,5,
- Akihiko Konagaya1,4,
- Takeshi Nagashima1,4, and
- Christian Schönbach1,6
- 1Biomedical Knowledge Discovery Team, Bioinformatics Group, RIKEN Genomic Sciences Center, Yokohama 230-0045, Japan
- 2Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
- 3Genome Science Laboratory, RIKEN, Hirosawa, Wako, Saitama 351-0198, Japan
- 4Department of Knowledge System Science, School of Knowledge Science, Advanced Institute of Science and Technology, Ishikawa, 923-1292, Japan
This extract was created in the absence of an abstract.
Peroxisomes, small vesicle-like subcellular respiratory organelles present in all eukaryotic cells, play a critical role in β-oxidation of fatty acids, glyoxylate metabolism, gluconeogenesis, and sterol biosynthetic pathway. The importance of peroxisomes for humans is stressed by the existence of a group of serious metabolic disorders caused either by impairment of peroxisome biogenesis or by defects of individual peroxisomal enzymes. Detailed cataloging of peroxisome proteins, “the peroxiproteome”, will significantly impact our understanding of peroxisome biology and aid in discovery of molecular targets to treat disorders associated with this organelle. …
