Identification of Novel “Pathologs” (Human Disease-Related Gene Candidates) From the RIKEN Full-Length Mouse cDNA Data Set
- Diego G. Silva1,2,
- Christian Schönbach3,
- Vladimir Brusic4,
- Luis A. Socha1,2,
- Takeshi Nagashima3,5,
- RIKEN GER Group6,
- GSL Members7,8, and
- Nikolai Petrovsky1,2,9
- 1Medical Informatics Centre, University of Canberra, ACT 2601 Australia
- 2John Curtin School of Medical Research, Australian National University, Canberra ACT 2601, Australia
- 3Biomedical Knowledge Discovery Team, Bioinformatics Group, RIKEN Genomic Sciences Center, Yokohama 230-0045, Japan
- 4Laboratories for Information Technology, Singapore 11961
- 5Department of Knowledge Systems Science, Japan Institute of Science and Technology, Ishikawa, 923-1292, Japan
- 6Laboratory for Genome Exploration Research Group, RIKEN Genomic Sciences Center (GSC), RIKEN Yokohama Institute, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045, Japan
- 7Genome Science Laboratory, RIKEN, Hirosawa, Wako, Saitama 351-0198, Japan
This extract was created in the absence of an abstract.
The majority of common diseases such as cancer, allergy, diabetes, or heart disease are characterized by complex genetic traits, in which genetic and environmental components contribute to disease susceptibility. Our knowledge of the genetic factors underlying most of such diseases is limited. A major goal in the post-genomic era is to identify and characterize disease susceptibility genes and to use this knowledge for disease treatment and prevention. More than 500 genes are conserved across the invertebrate and vertebrate genomes. Because of gene conservation, various organisms including yeast, fruitfly, zebrafish, rat, and mouse have been used as genetic models …
