Lymphopenia in the BB Rat Model of Type 1 Diabetes is Due to a Mutation in a Novel Immune-Associated Nucleotide (Ian)-Related Gene

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Figure 3.
Figure 3.

Sequence comparisons between BBDR wild-type (+/+), lyp/lyprat, mouse, and human Immune Associated Nucleotide-5 (Ian5) and mouse Ian4 predicted amino acid sequences. The deletion of a nucleotide in the codon for amino acid 85 of the rIan5(lyp) changes the predicted downstream amino acids to include 19 amino acids (italicized) before the premature STOP codon at amino acid position 104. Putative ATP/GTP-binding sites are boxed/shadowed and a hydrophobic putative transmembrane region underlined.

This Article

  1. Genome Res. 12: 1029-1039

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