Vestibular Dysfunction in the Epistatic circler Mouse Is Caused by Phenotypic Interaction of One Recessive Gene and Three Modifier Genes

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Figure 2.
Figure 2.

Liability scale for equal and additive effects for theEcl-genes. The number of risk Ecl-alleles is plotted on the X-axis; the fraction of F2-animals (47 noncircling and 91 circling F2-mice) is plotted on the Y-axis. Although we were not able to determine a threshold, there is a clear shift in the number of affected alleles between unaffected and affected F2 animals.

This Article

  1. Published in Advance March 20, 2002, doi: 10.1101/gr.218402 Genome Res. 12: 613-617

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